Summary of sample preparation methods

author:

The complete sample analysis process includes sample collection, sample preparation, analytical determination, data processing and reporting of results, and sample preparation is arguably the most important link. Not only because sample pretreatment takes up more than 60% of the time of the entire sample analysis process, but also because this link is the most prone to analytical errors. Below we will start a detailed description of the sample pretreatment.

Why sample preparation? :

1. In the complex system, the components to be tested are separated from the matrix, and the concentration is increased by purification and enrichment, and the solution is made into a solution that is convenient for measurement.
2. Remove impurities that interfere with analytical determination;
3. The sample is processed by a sample derivatization technique to quantitatively convert a sample that is originally weak or non-responsive to the detector into an easily detectable compound.

General principles of sample preparation:

1. In-depth understanding of the characteristics of the sample, the detection method and the performance of the analytical instrument used.
2. The pretreatment method should be as simple and fast as possible to minimize the pollution to the environment.
3. The viscosity of the sample should not be too large to prevent clogging of the column, nozzle and capillary inlet
4. The sample must not be contaminated, and the components to be tested and substances that interfere with the determination cannot be introduced.
5. Minimize the chemical changes of the tested components as much as possible and inhibit the loss of the tested components.